Grapes in the southern half of the state will soon be reaching the critical pre-bloom stage, which is a key time to control important diseases such as black rot, downy mildew, and powdery mildew. The three or four sprays made from immediate pre-bloom to 4 weeks post bloom are critical for controlling fruit infections. Growers should pay extra attention to coverage, especially in the fruit zone, and use the best fungicides available. The Midwest Fruit Pest Management Guide lists recommended products. A protectant (FRAC M) such as mancozeb or captan plus one of the sterol inhibitors (FRAC 3) such as Bayleton, Mettle, Procure, Rally or Tebuzol is the recommended fungicide treatment. Rotating with a different mode of action, such the strobilurins (FRAC 11) Abound, Sovran, or Flint is a good option as well. The combination products such as Pristine, Inspire Super, Revus Top, Quadris Top and Adamant are also effective for broad-spectrum disease control. Be sure to read the warnings about phytotoxicity with fungicides containing difenoconazole. These next few sprays are critical to producing sound, clean fruit. Pay attention to detail now to assure excellent fruit quality at harvest. This is the most important time of the year for disease control. Once we get 4 to 5 weeks past fruit set, disease pressure drops significantly.